Insilico structural analysis of parasporin 2 protein sequences of non-toxic bacillus thuringiensis
نویسندگان
چکیده
منابع مشابه
Structural Insights into Bacillus thuringiensis Cry, Cyt and Parasporin Toxins
Since the first X-ray structure of Cry3Aa was revealed in 1991, numerous structures of B. thuringiensis toxins have been determined and published. In recent years, functional studies on the mode of action and resistance mechanism have been proposed, which notably promoted the developments of biological insecticides and insect-resistant transgenic crops. With the exploration of known pore-formin...
متن کاملParasporin, a new anticancer protein group from Bacillus thuringiensis.
Parasporin (PS) is a collection of genealogically heterogeneous Cry proteins synthesized in Bacillus thuringiensis. A prominent feature commonly associated with PS proteins is the strong cytocidal activity preferential for human cancer cells of various origins. The proteins exhibit cytocidal activities only when digested with proteases. Currently, this protein group is classified into four fami...
متن کاملOligomerization of Parasporin-2, a �ew Crystal Protein from �on-Insecticidal Bacillus thuringiensis�� in Lipid Rafts
Parasporin-2, a new crystal protein from non-insecticidal Bacillus thuringiensis, exhibits strong cytocidal activity against various mammalian cells with divergent target specificity. The toxin binds to the surface of target cells and increases permeability of plasma membrane. Subcellular fractionation and immunoblot analysis of the toxin-treated cells revealed that the toxin bound to lipid raf...
متن کاملIdentification of parasporin genes in Vietnamese isolates of Bacillus thuringiensis.
Four genes encoding parasporins, cytotoxins preferentially killing human cancer cells in vitro, were isolated from four Vietnamese strains of Bacillus thuringiensis. Nucleotide sequence analysis revealed that: (1) three genes fall into the two known classes, ps1Aa and ps1Ab, and (2) another one belongs to ps1Ac, a novel gene class established in this study. Upon proteolytic activation, paraspor...
متن کاملCharacterization of parasporin gene harboring Indian isolates of Bacillus thuringiensis
Bacillus thuringiensis (Bt) is popularly known as insecticidal bacterium. However, non-insecticidal Bt strains are more extensively available in natural environment than the insecticidal ones. Parasporin (PS) is a collection of genealogically heterogeneous Cry proteins synthesized in non-insecticidal isolates of Bt. An important character generally related with PS proteins is their strong cytoc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomedical Science and Engineering
سال: 2010
ISSN: 1937-6871,1937-688X
DOI: 10.4236/jbise.2010.34057